Endocrine Abstracts

Ghrelin, a recently isolated hormone, has been reported to have modulatory effects on smooth muscle contractility. In this study, we investigated the effects of ghrelin on spontaneous contractions in the rat uterus in vitro.Myometrium strips were removed from Wistar rats following decapitation and placed in a jacked tissue bath containing Krebs solution at 37 oC and pH 7.4, constantly bubbled with 95% oxygen and 5% carbon dioxide. The myometrial strips w...

Seminal vesicles play important roles in male infertility due to their secretions and contractile properties. Beside their sympathetic and parasympathetic nerve supply, seminal vesicles are also innervated by purinergic stimuli. Additionally, prolactin affects the gonadal, seminal vesicle, prostate functions and contributes to seminal plasma and sexual function. Medical treatment of hyperprolactinemia usually involves dopamine agonists. In the present study, effects of treated...

Nebivolol is a recently developed beta(1)-selective adrenergic receptor antagonist with proposed nitric oxide mediated vasodilating properties. Effect of nebivolol on vascular smooth muscle has been attributed to estrogen receptor-mediated vascular responsiveness. Although it is known that nitric oxide has relaxing effect on myometrium, there is no report whether nebivolol application affect myometrial contractility. Therefore, we have investigated the effect of nebivolol on r...

Various abnormalities of coagulation may occur in patients with thyroid disorders and may range from subclinical laboratory abnormalities to clinically significant disturbances of coagulation. Tissue factor pathway inhibitor (TFPI) is a newly determined potent inhibitor of tissue factor dependent coagulation system. TFPI changes in various thyroid disorders has not been evaluated yet. In this study we have evaluated total TFPI (tTFPI), free TFPI (fTFPI), tissue plasminogen act...